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Weinberger, Raphael; Linden, Mark van der; Imöhl, Matthias; Kries, Rüdiger von (2016): Vaccine effectiveness of PCV13 in a 3+1 vaccination schedule. In: Vaccine, Vol. 34, No. 18: pp. 2062-2065
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Objective: To assess the vaccine effectiveness (VE) of PCV13 for invasive pneumococcal disease (IPD) regarding the extra six serotypes with a 3 + 1 schedule in Germany. Methods: Active surveillance for IPD in children <16 years eligible for PCV13 vaccination. We used the Broome method and logistic regression to estimate VE. Results: Data on 164/304 reported IPD cases were informative and met the inclusion criteria. VE for the extra six serotypes was 88% [95% confidence interval (CI): 73;95] and 83% [56;94] for at least one and for at least two doses respectively. VE for the complete 3 +1 vaccination schedule was not conclusive because of a wide 95% CI. For serotype 3 VE appeared to be zero with an even wider 95% Cl. Conclusion: PCV13 VE against the extra six serotypes with the 3 +1 schedule in Germany was only marginally higher compared to previously published data for the 2+1 schedule. (C) 2016 Elsevier Ltd. All rights reserved.