Die metabolische Selbstzerstörung des kritisch kranken Patienten (Teil I): Evolutionsbiologische Hintergründe, Mechanismen und Sinnhaftigkeit

Hartl, W. H. (2016): Die metabolische Selbstzerstörung des kritisch kranken Patienten (Teil I): Evolutionsbiologische Hintergründe, Mechanismen und Sinnhaftigkeit. In: Aktuelle Ernährungsmedizin, Bd. 41, Nr. 1: S. 40-44

Abstract

The present study wants to analyse potentially self-destructive metabolic responses observed in critically ill patients from an evolutionary perspective specifically focusing on origins, nature, and principal usefulness. Metabolic reactions associated with surgical injury or infection comprise hyperglycemia, insulin resistance, increased hepatic glucose production and muscle protein breakdown. From an evolutionary perspective these responses have been necessary and successful to overcome spontaneously survivable insults (minor surgical trauma) by maintaining function of immune-competent and reparative cells. There is, however, overwhelming evidence that extreme metabolic responses have not been selected by evolution, but may have persisted because of unavoidable evolutionary constraints.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0341-0501
• Sprache: Deutsch