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Hartl, W. H. (2016): Die metabolische Selbstzerstörung des kritisch kranken Patienten (Teil II): Die Bedeutung der modernen Medizin und therapeutische Konsequenzen. In: Aktuelle Ernährungsmedizin, Bd. 41, Nr. 2: S. 113-117

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Abstract

Modern emergency and intensive care medicine allows patients to survive even extreme disturbances of their homeostasis. This progress, however, has modified utility of originally advantageous metabolic reactions (hyperglycemia, muscle protein catabolism) to a point where their activation is exaggerated thereby revealing auto-destructive elements. Potentially detrimental side effects of metabolic reactions result from their quantity which is determined by extent and duration of the disturbance of homeostasis. Self-destructive metabolic responses cannot be prevented by adjuvant therapies such as artificial nutrition which may only help to ameliorate secondary metabolic damage. Effective treatment is only possible by a simultaneous aggressive therapy of underlying pathologies (such as shock, trauma or infection) thereby interrupting secondary metabolic trigger mechanisms at an early stage.

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