Die sporadische zerebrale Amyloidangiopathie – eine aktuelle Übersicht mit klinischen Fallbeispielen

Schöberl, F.; Eren, O. E.; Wollenweber, F. A.; Kraus, T. und Kellert, L. (2016): Die sporadische zerebrale Amyloidangiopathie – eine aktuelle Übersicht mit klinischen Fallbeispielen. In: Fortschritte der Neurologie, Psychiatrie, Bd. 84, Nr. 9: S. 534-541

Abstract

Sporadic cerebral amyloid angiopathy (CAA) is a cerebral small vessel disease in the elderly. Neuropathologically, it is characterized by deposition of amyloid-beta (A beta) in the wall of small to mediumsized arteries, capillaries and venules of the cerebral cortex and leptomeninges. Over the last years it was recognized as an important cause of spontaneous intracerebral hemorrhage and cognitive deficits in the elderly. The clinical and radiological manifestations are diverse ranging from acute onset focal neurological deficits due to intracerebral lobar hemorrhage to subacute progressive cognitive impairment due to A beta-mediated inflammation confluent subcortical edema. The wide clinico-radiological spectrum of CAA is a major challenge for the neurologist and stroke physician. This review provides a structured and detailed look at recent developments in CAA, and is illustrated with case studies.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0720-4299
• Sprache: Deutsch