ORCID: https://orcid.org/0000-0002-1804-9756; Dejean, Cyril; Chaudun, Fabrice; Khoder, Suzana; Rozeske, Robert R.; Wurtz, Hélène; Bagur, Sophie; Benchenane, Karim; Sirota, Anton
ORCID: https://orcid.org/0000-0002-4700-6587; Courtin, Julien und Herry, Cyril
(2016):
4-Hz oscillations synchronize prefrontal-amygdala circuits during fear behavior.
In: Nature Neuroscience, Bd. 19, Nr. 4: S. 605-612
Abstract
Fear expression relies on the coordinated activity of prefrontal and amygdala circuits, yet the mechanisms allowing long-range network synchronization during fear remain unknown. Using a combination of extracellular recordings, pharmacological and optogenetic manipulations, we found that freezing, a behavioral expression of fear, temporally coincided with the development of sustained, internally generated 4-Hz oscillations in prefrontal-amygdala circuits. 4-Hz oscillations predict freezing onset and offset and synchronize prefrontal-amygdala circuits. Optogenetic induction of prefrontal 4-Hz oscillations coordinates prefrontal-amygdala activity and elicits fear behavior. These results unravel a sustained oscillatory mechanism mediating prefrontal-amygdala coupling during fear behavior.
Dokumententyp: | Zeitschriftenartikel |
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Fakultät: | Medizin > Lehrstuhl für Kognition und Neuronale Plastizität |
Themengebiete: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit |
ISSN: | 1097-6256 |
Sprache: | Englisch |
Dokumenten ID: | 44801 |
Datum der Veröffentlichung auf Open Access LMU: | 27. Apr. 2018, 08:07 |
Letzte Änderungen: | 28. Okt. 2021, 12:08 |