4-Hz oscillations synchronize prefrontal-amygdala circuits during fear behavior

Karalis, Nikolaos ; Dejean, Cyril; Chaudun, Fabrice; Khoder, Suzana; Rozeske, Robert R.; Wurtz, Hélène; Bagur, Sophie; Benchenane, Karim; Sirota, Anton ; Courtin, Julien und Herry, Cyril (2016): 4-Hz oscillations synchronize prefrontal-amygdala circuits during fear behavior. In: Nature Neuroscience, Bd. 19, Nr. 4: S. 605-612

Abstract

Fear expression relies on the coordinated activity of prefrontal and amygdala circuits, yet the mechanisms allowing long-range network synchronization during fear remain unknown. Using a combination of extracellular recordings, pharmacological and optogenetic manipulations, we found that freezing, a behavioral expression of fear, temporally coincided with the development of sustained, internally generated 4-Hz oscillations in prefrontal-amygdala circuits. 4-Hz oscillations predict freezing onset and offset and synchronize prefrontal-amygdala circuits. Optogenetic induction of prefrontal 4-Hz oscillations coordinates prefrontal-amygdala activity and elicits fear behavior. These results unravel a sustained oscillatory mechanism mediating prefrontal-amygdala coupling during fear behavior.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin > Lehrstuhl für Kognition und Neuronale Plastizität
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1097-6256
• Sprache: Englisch