Age-related myelin degradation burdens the clearance function of microglia during aging

Safaiyan, Shima; Kannaiyan, Nirmal; Snaidero, Nicolas; Brioschi, Simone; Biber, Knut; Yona, Simon; Edinger, Aimee L.; Jung, Steffen; Rossner, Moritz J. und Simons, Mikael (2016): Age-related myelin degradation burdens the clearance function of microglia during aging. In: Nature Neuroscience, Bd. 19, Nr. 8: S. 995-998

Abstract

Myelin is synthesized as a multilamellar membrane, but the mechanisms of membrane turnover are unknown. We found that myelin pieces were gradually released from aging myelin sheaths and were subsequently cleared by microglia. Myelin fragmentation increased with age and led to the formation of insoluble, lipofuscin-like lysosomal inclusions in microglia. Thus, age-related myelin fragmentation is substantial, leading to lysosomal storage and contributing to microglial senescence and immune dysfunction in aging.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1097-6256
• Sprache: Englisch