The role of TF- and Tn-antigens in breast cancer metastasis

Kölbl, Alexandra C.; Jeschke, Udo; Friese, Klaus und Andergassen, Ulrich (2016): The role of TF- and Tn-antigens in breast cancer metastasis. In: Histology and Histopathology, Bd. 31, Nr. 6: S. 613-621

Abstract

Almost 40 years ago, researchers found that the Thomsen-Friedenreich (TF) and the Thomsen nouvelle (Tn) antigens could be detected in carcinoma, but not in healthy tissue. A short time after that it became clear that TF and Tn are precursor molecules of the MN-blood group antigens. In normal tissue TF and Tn are coated by glycosyl structures, thereby forming the glycoproteins which are known to account for the MN-blood group antigens, but in malignant tissue these molecules are uncovered. TF, which has an additional Galectin-residue compared to Tn, is correlated with a more favourable prognosis for patients. On the contrary, patients with Tn-bearing tissues have a worse prognosis for overall and progression-free survival. It is known that TF and Tn are involved in the adhesion of tumour cells to the endothelium via a mechanism recruiting Galectin-3 and MUC-1, which is the first step in metastasis formation. Furthermore, it became clear that this pathway can be blocked by a growing number of molecules, thereby creating ways of therapeutical intervention.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0213-3911
• Sprache: Englisch