Biologically optimized helium ion plans: calculation approach and its in vitro validation

Mairani, A.; Dokic, I.; Magro, G.; Tessonnier, T.; Kamp, F.; Carlson, D. J.; Ciocca, M.; Cerutti, F.; Sala, P. R.; Ferrari, A.; Böhlen, T. T.; Jäkel, O.; Parodi, K.; Debus, J.; Abdollahi, A. und Haberer, T. (2016): Biologically optimized helium ion plans: calculation approach and its in vitro validation. In: Physics in Medicine and Biology, Bd. 61, Nr. 11: S. 4283-4299

Abstract

Treatment planning studies on the biological effect of raster-scanned helium ion beams should be performed, together with their experimental verification, before their clinical application at the Heidelberg Ion Beam Therapy Center (HIT). For this purpose, we introduce a novel calculation approach based on integrating data-driven biological models in our Monte Carlo treatment planning (MCTP) tool. Dealing with a mixed radiation field, the biological effect of the primary He-4 ion beams, of the secondary He-3 and 4He (Z = 2) fragments and of the produced protons, deuterons and tritons (Z = 1) has to be taken into account. A spread-out Bragg peak (SOBP) in water, representative of a clinically-relevant scenario, has been biologically optimized with the MCTP and then delivered at HIT. Predictions of cell survival and RBE for a tumor cell line, characterized by (alpha/beta)(ph) = 5.4 Gy, have been successfully compared against measured clonogenic survival data. The mean absolute survival variation (mu(Delta S)) between model predictions and experimental data was 5.3% +/- 0.9%. A sensitivity study, i.e. quantifying the variation of the estimations for the studied plan as a function of the applied phenomenological modelling approach, has been performed. The feasibility of a simpler biological modelling based on dose-averaged LET (linear energy transfer) has been tested. Moreover, comparisons with biophysical models such as the local effect model (LEM) and the repair-misrepair- fixation (RMF) model were performed. mu(Delta S) values for the LEM and the RMF model were, respectively, 4.5% +/- 0.8% and 5.8% +/- 1.1%. The satisfactorily agreement found in this work for the studied SOBP, representative of clinically-relevant scenario, suggests that the introduced approach could be applied for an accurate estimation of the biological effect for helium ion radiotherapy.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0031-9155
• Sprache: Englisch