Embryonale Bauchtumoren im Kindes- und Jugendalter

Eggert, Angelika; Simon, Thorsten; Schweinitz, Dietrich von; Timmermann, Beate und Graf, Norbert (2016): Embryonale Bauchtumoren im Kindes- und Jugendalter. In: Onkologe, Bd. 22, Nr. 12: S. 940-953

Abstract

The embryonal tumors neuroblastoma, nephroblastoma and hepatoblastoma are important differential diagnoses to be considered for abdominal neoplasms, particularly in infants. Clinical symptoms are often mild and unspecific and the proportion of incidental diagnoses is relatively high. Diagnostics, therapy and outcome Current diagnostics include assessment of specific tumor markers, defined staging analyses based on imaging and histological and molecular analyses of tumor tissue. Diagnostics and treatment are exclusively provided by specialized pediatric oncology centers with multidisciplinary expertise in the framework of defined therapy optimization trials. Whereas the outcome for patients with nephroblastoma and hepatoblastoma is very good even for metastasized disease, the long-term survival rate is < 40 % for patients with metastasized neuroblastoma. State of the art sequencing technologies enable increasingly more precise tumor classification and outcome prediction based on characteristic molecular patterns and the rational selection of experimental therapies for recurrent disease situations.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0947-8965
• Sprache: Deutsch