Stimulation of Central alpha 2 Receptors Attenuates Experimental Necrotizing Pancreatitis

Schneider, Lutz; Jabrailova, Bahar; Salem, Mohammed; Kilk, Karl; Hofer, Stefan; Brenner, Thorsten; Strobel, Oliver; Hackert, Thilo und Werner, Jens (2016): Stimulation of Central alpha 2 Receptors Attenuates Experimental Necrotizing Pancreatitis. In: Pancreas, Bd. 45, Nr. 2: S. 260-264

Abstract

Objectives Severe necrotizing pancreatitis (SNP) is a disease with relevant morbidity and mortality until today. No specific therapy is in sight. Central 2 agonists such as clonidine and dexmedetomidine are known to have anti-inflammatory effects though the cholinergic anti-inflammatory pathway and are implemented in the clinical routine as adjunct sedative drugs. Their potential effect on SNP has not yet been tested. Methods Severe necrotizing pancreatitis was induced in male Wistar rats. Four treatment groups received either clonidine or dexmedetomidine before (prophylactic) or after induction of SNP (therapeutic). After 12 hours, pancreatic morphologic injury, systemic proinflammatory high-mobility group box 1 protein, and pancreatic and pulmonary myeloperoxidase levels were evaluated. Results Severe necrotizing pancreatitis was fully established 12 hours after induction. Prophylactic and therapeutic administration of clonidine and dexmedetomidine reduced pancreatic morphologic injury (P < 0.05 vs SNP), serum proinflammatory high-mobility group box 1 protein (P < 0.0001 vs SNP), as well as pancreatic and pulmonary myeloperoxidase levels (P < 0.01 vs SNP). Conclusions Prophylactic and therapeutic applications of the central 2 agonists clonidine and dexmedetomidine are effective to attenuate local and systemic injury in experimental SNP and should be evaluated in the clinical setting.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0885-3177
• Sprache: Englisch