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Nickel, T.; Lackermair, K.; Scherr, J.; Calatzis, A.; Vogeser, M.; Hanssen, H.; Waidhauser, G.; Schönermark, U.; Methe, H.; Horster, S.; Wilbert-Lampen, U.; Halle, M. (2016): Influence of high polyphenol beverage on stress-induced platelet activation. In: Journal of Nutrition Health & Aging, Vol. 20, No. 6: pp. 586-593
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Abstract

Platelets are playing a crucial role in acute cardiovascular events. We investigated if physical stress activates platelets and whether this activation can be inhibited by a polyphenol-enriched diet. Blood samples were taken from a total of 103 athletes three weeks before, one day before, immediately as well as 24 hours and 72 hours after a marathon run. Participants were randomized, double-blinded and divided into two groups. One group received a polyphenol-rich beverage the other the same beverage without polyphenols. Besides analysis of platelet counts and impedance-aggregometric-measurement of platelet activity, soluble P-selectin and Endothelin-A measurements were performed. In the control group, runners showed a 2.2-fold increased platelet aggregation directly after completing a marathon and within the following three days when compared with baseline values (p < 0.01). In accordance, significant increases in sP-selectin (57.52ng/ml vs. 94.86ng/ml;p < 0.01) were detectable. In contrast, for the group consuming a beverage with increased polyphenol content (upper quartile of study beverage intake) we did not find any increase of platelet aggregation. Physical stress causes a significant increase in platelet activity. Our results demonstrate that a diet enriched in polyphenols is capable of preventing platelet activation. These findings might indicate a diminished cardiovascular stress-reaction following pre-exposition to polyphenol-enriched diet.