Postoperative peak serum C-reactive protein is a predictor of outcome following liver transplantation for hepatocellular carcinoma

Kornberg, Arno; Witt, Ulrike; Kornberg, Jennifer; Müller, Katharina; Friess, Helmut und Thrum, Katharina (2016): Postoperative peak serum C-reactive protein is a predictor of outcome following liver transplantation for hepatocellular carcinoma. In: Biomarkers, Bd. 21, Nr. 2: S. 152-159

Abstract

Context: C-reactive protein (CRP), a biomarker of inflammation, may correlate with prognosis in several malignancies. Objective: To investigate the prognostic impact of early postoperative peak serum levels of CRP on tumor-specific outcome in 106 liver transplant patients with hepatocellular carcinoma (HCC). Methods and results: In multivariate Cox regression analysis, a posttransplant elevated peak CRP level (>versus <= 3.5 mg/dl) was identified as an independent predictor of poor recurrence-free survival (p = 0.01;HR = 4.04;CI = 1.399-11.640). Conclusion: Early postoperative serum CRP may serve as a useful inflammation-based biomarker of outcome in liver transplant patients with HCC.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1354-750X
• Sprache: Englisch