Autoimmunreaktionen bei Psoriasis

Prinz, J. C. (2016): Autoimmunreaktionen bei Psoriasis. In: Hautarzt, Bd. 67, Nr. 6: S. 432-437

Abstract

Psoriasis is a human leukocyte antigen (HLA)-associated TaEurocell-mediated disorder. The role of the main psoriasis risk allele HLA-C*06:02 in disease manifestation and the mechanisms which activate the pathogenic TaEurocell response in the skin of psoriasis patients remained elusive. Key to the immune pathogenesis of psoriasis was the analysis of the specificity of the infiltrating lesional psoriatic CD8(+) T cells Analyses of the lesional psoriatic TaEurocell reactivity demonstrate that psoriasis is an autoimmune disease. It is based on an autoimmune response against melanocytes which is preferentially mediated by HLA-C*06:02 through autoantigen presentation. Here we discuss the mechanisms of this autoimmune response in the context of the polygenic psoriatic predisposition.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0017-8470
• Sprache: Deutsch