Logo Logo
Hilfe
Hilfe
Switch Language to English

Schilbach, Katharina und Schopohl, Jochen (2016): Update on the use of oral octreotide therapy for acromegaly. In: Expert Review of Endocrinology & Metabolism, Bd. 11, Nr. 4: S. 349-355

Volltext auf 'Open Access LMU' nicht verfügbar.

Abstract

Introduction: Somatostatin analogs are most commonly used in pharmacological treatment of acromegaly. Pegvisomant and dopamine agonists are alternatives, which are used to a lesser extent. Dopamine agonists are the only orally applicable medication but are less effective than the other options. For a large number of patients, life-long pharmacotherapy has to be applied and frequent injections represent a reduction of quality of life for many of them. Areas covered: Recently published evidence for the use of oral octreotide therapy for acromegaly. Expert commentary: Oral octreotide is a novel and effective treatment for acromegaly and the side effects have been shown to be comparable to the injectable SSAs. The combination with a transient permeability enhancer allows intestinal permeation but also enables molecules with a size <70 kDa to pass transiently. This does not seem to have an acute or subacute consequence, but the long-term effect is still elusive. Therefore, more long-term trials are desirable.

Dokument bearbeiten Dokument bearbeiten