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Prell, C. and Koletzko, B. (2016): Hyperlipidämien im Kindes- und Jugendalter.Diagnostik und Therapie. In: Monatsschrift Kinderheilkunde, Vol. 164, No. 9: pp. 813-828

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Abstract

Disorders of lipid metabolism in childhood and adolescence are relevant risk factors for later development of cardiovascular diseases;therefore, the diagnostic work-up and treatment should be initiated early on. A positive family history is the first indication of hyperlipidemia (Synonym hyperlipoproteinemia, HLP). Testing of total cholesterol should be offered to every child or adolescent within the framework of a screening program, regardless of family history. Further diagnostic work-up in cases of suspected HLP includes a fasting blood sample for the determination of plasma lipids and other parameters in order to exclude secondary HLP as well as the measurement of the intima media thickness in the carotid artery. Therapy of HLP consists of a fat-modified diet, lifestyle changes and drug therapy options. The care of patients should be based on current guidelines and a close cooperation between the primary care pediatrician, pediatric dieticians and specialists from a pediatric lipid metabolism outpatient department.

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