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Kim, Bong-Sung; Jacobs, Denise; Emontzpohl, Christoph; Goetzenich, Andreas; Soppert, Josefin; Jarchow, Mareike; Schindler, Lisa; Averdunk, Luisa; Kraemer, Sandra; Marx, Gernot; Bernhagen, Jürgen; Pallua, Norbert; Schlemmer, Heinz-Peter; Simons, David and Stoppe, Christian (2016): Myocardial Ischemia Induces SDF-1α Release in Cardiac Surgery Patients. In: Journal of Cardiovascular Translational Research, Vol. 9, No. 3: pp. 230-238

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In the present observational study, we measured serum levels of the chemokine stromal cell-derived factor-1 alpha (SDF-1 alpha) in 100 patients undergoing cardiac surgery with cardiopulmonary bypass at seven distinct time points including preoperative values, myocardial ischemia, reperfusion, and the postoperative course. Myocardial ischemia triggered a marked increase of SDF-1 alpha serum levels whereas cardiac reperfusion had no significant influence. Perioperative SDF-1 alpha serum levels were influenced by patients' characteristics (e.g., age, gender, aspirin intake). In an explorative analysis, we observed an inverse association between SDF-1 alpha serum levels and the incidence of organ dysfunction. In conclusion, time of myocardial ischemia was identified as the key stimulus for a significant upregulation of SDF-1 alpha, indicating its role as a marker of myocardial injury. The inverse association between SDF-1 alpha levels and organ dysfunction association encourages further studies to evaluate its organoprotective properties in cardiac surgery patients.

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