New insights on pleural fluid formation: potential translational targets

Vreka, Malamati; Klotz, Laura V. und Stathopoulos, Georgios T. (2016): New insights on pleural fluid formation: potential translational targets. In: Current Pulmonology Reports, Bd. 5, Nr. 1: S. 35-39

Abstract

Pleural effusion is a very common clinical problem associated with a multitude of different underlying conditions, including infection, heart failure, and cancer. Current treatments for pleural effusion often aim at symptom relief rather than at treating its underlying cause. Recent investigations have provided new insights into the mechanisms of fluid accumulation in the pleural space and hence hope for clinical translation of the novel therapy to stop fluid formation. Here, we discuss the major mechanistic findings of recent basic, translational, and clinical studies that have aimed at tackling the management and the pathobiology of the most common types of pleural effusions. In addition, we analyze the current and potential future uses of these novel data in the management of patients with pleural effusion.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• Sprache: Englisch