Endometrial Adenocarcinoma: Analysis of Circulating Tumour Cells by RT-qPCR

Koelbl, Alexandra C.; Wellens, Rebekka; Koch, Julian; Rack, Brigitte; Hutter, Stefan; Friese, Klaus; Jeschke, Udo und Andergassen, Ulrich (2016): Endometrial Adenocarcinoma: Analysis of Circulating Tumour Cells by RT-qPCR. In: Anticancer Research, Bd. 36, Nr. 6: S. 3205-3209

Abstract

Background: Endometrial adenocarcinoma is a frequently occurring cancer in women, accounting for 42,000 deaths every year. Despite treatment with standard therapy, occurrence of remote metastases and local recurrences is high. Through help of RT-qPCR minimal residual disease could be detected and characterized, facilitating therapeutic decision making. Materials and Methods: A number of marker genes were first tested in model systems and genes that performed best, were consequently used for the examination of 13 blood samples from endometrial carcinoma patients. Results: Cytokeratin 19 and MIG7 were chosen for the analysis in patient samples. Both genes were found up-regulated in small tumours and in one large tumour, but no statistical correlations could be revealed between expression levels of these two genes and tumour characteristics. Conclusion: There seems to be a coherence between gene expression and the stage of tumorigenesis, but the number of samples is still too small, to be able to obtain statistical significant differences.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0250-7005
• Sprache: Englisch