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Koelbl, Alexandra C.; Wellens, Rebekka; Koch, Julian; Rack, Brigitte; Hutter, Stefan; Friese, Klaus; Jeschke, Udo; Andergassen, Ulrich (2016): Endometrial Adenocarcinoma: Analysis of Circulating Tumour Cells by RT-qPCR. In: Anticancer Research, Vol. 36, No. 6: pp. 3205-3209
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Background: Endometrial adenocarcinoma is a frequently occurring cancer in women, accounting for 42,000 deaths every year. Despite treatment with standard therapy, occurrence of remote metastases and local recurrences is high. Through help of RT-qPCR minimal residual disease could be detected and characterized, facilitating therapeutic decision making. Materials and Methods: A number of marker genes were first tested in model systems and genes that performed best, were consequently used for the examination of 13 blood samples from endometrial carcinoma patients. Results: Cytokeratin 19 and MIG7 were chosen for the analysis in patient samples. Both genes were found up-regulated in small tumours and in one large tumour, but no statistical correlations could be revealed between expression levels of these two genes and tumour characteristics. Conclusion: There seems to be a coherence between gene expression and the stage of tumorigenesis, but the number of samples is still too small, to be able to obtain statistical significant differences.