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Cosgarea, Raluca; Juncar, Raluca; Heumann, Christian; Tristiu, Roxana; Lascu, Liana; Arweiler, Nicole; Stavropoulos, Andreas; Sculean, Anton (2016): Non-surgical periodontal treatment in conjunction with 3 or 7days systemic administration of amoxicillin and metronidazole in severe chronic periodontitis patients. A placebo-controlled randomized clinical study. In: Journal of Clinical Periodontology, Vol. 43, No. 9: pp. 767-777
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Abstract

AimTo evaluate the effect of 3 or 7days systemic administration of amoxicillin (AMX) and metronidazole (MET) or placebo as adjunct to non-surgical periodontal treatment in severe chronic periodontitis patients. MethodsOne hundred and two patients with severe chronic periodontitis [e.g. 1 site with probing pocket depth (PD)6mm per quadrant] were randomly divided into three equally sized groups and treated with either scaling and root planing within 24h (SRP)+placebo (Group A) or SRP+AMX+MET (both 500mgx3 times daily) for 3days (Group B) or SRP+AMX+MET (both 500mgx3 times daily) for 7days (Group C). PD, clinical attachment level (CAL), bleeding on probing (BOP), full-mouth plaque scores (FMPS) and gingival bleeding index (GBI) were assessed prior to treatment (baseline), and at 3 and 6months post-treatment. The primary outcome variable was the difference () in the number of sites with PD6mm. ResultsNinety-one patients completed the study. At both 3 and 6months, all three treatment protocols resulted in statistically significant improvements compared to baseline for all evaluated clinical parameters (p<0.001). At 6months, astatistically significantly greater reduction in the mean number of sites with PD6mm was observed in group B (28.6215.32 sites) and group C (30.45 +/- 15.04 sites) compared to the placebo group (17.10 +/- 14.68 sites). Furthermore, both the 3- and the 7-day antibiotic regimen resulted in statistically significantly higher clinical improvements compared to the placebo group (p<0.05). ConclusionThe present findings indicate that in patients with severe chronic periodontitis, non-surgical periodontal therapy in conjunction with a 3 or 7days systemic administration of AMX+MET may lead to significantly greater clinical improvements compared to non-surgical therapy alone.