In vivo pink-beam imaging and fast alignment procedure for rat brain tumor radiation therapy

Nemoz, Christian; Kibleur, Astrid; Hyacinthe, Jean Noel; Berruyer, Gilles; Brochard, Thierry; Bräuer-Krisch, Elke; Le Duc, Geraldine; Brun, Emmanuel; Elleaume, Helene und Serduc, Raphael (2016): In vivo pink-beam imaging and fast alignment procedure for rat brain tumor radiation therapy. In: Journal of Synchrotron Radiation, Bd. 23: S. 339-343

Abstract

A fast positioning method for brain tumor microbeam irradiations for preclinical studies at third-generation X-ray sources is described. The three-dimensional alignment of the animals relative to the X-ray beam was based on the X-ray tomography multi-slices after iodine infusion. This method used pink-beam imaging produced by the ID17 wiggler. A graphical user interface has been developed in order to define the irradiation parameters: field width, height, number of angles and X-ray dose. This study is the first reporting an image guided method for soft tissue synchrotron radiotherapy. It allowed microbeam radiation therapy irradiation fields to be reduced by a factor of similar to 20 compared with previous studies. It permitted more targeted, more efficient brain tumor microbeam treatments and reduces normal brain toxicity of the radiation treatment.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Physik
• Themengebiete: 500 Naturwissenschaften und Mathematik > 530 Physik
• ISSN: 1600-5775
• Sprache: Englisch