Abstract
A fast positioning method for brain tumor microbeam irradiations for preclinical studies at third-generation X-ray sources is described. The three-dimensional alignment of the animals relative to the X-ray beam was based on the X-ray tomography multi-slices after iodine infusion. This method used pink-beam imaging produced by the ID17 wiggler. A graphical user interface has been developed in order to define the irradiation parameters: field width, height, number of angles and X-ray dose. This study is the first reporting an image guided method for soft tissue synchrotron radiotherapy. It allowed microbeam radiation therapy irradiation fields to be reduced by a factor of similar to 20 compared with previous studies. It permitted more targeted, more efficient brain tumor microbeam treatments and reduces normal brain toxicity of the radiation treatment.
| Item Type: | Journal article |
|---|---|
| Faculties: | Physics |
| Subjects: | 500 Science > 530 Physics |
| ISSN: | 1600-5775 |
| Language: | English |
| Item ID: | 47781 |
| Date Deposited: | 27. Apr 2018, 08:13 |
| Last Modified: | 04. Nov 2020, 13:24 |
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