Abstract
Scalable continuous flow procedures are reported for the metalation and downstream functionalization of beta-substituted acrylates. The flow conditions allow the metalation Of acrylonitriles, acrylates, and nitroolefins at 0.25-2.50 mmol/min conversion rates. Magnesiations can be performed with short residence times (1-20 min) and near-ambient temperature using TMPMgCl center dot LiCl. Further, high temperature zincation (<= 90 degrees C) using TMPZnCl.LiCl is possible. This method allows a simple entry to 2(5H)-furanones by flow generation of magnesiated acrylates and a subsequent reaction with aldehydes.
Dokumententyp: | Zeitschriftenartikel |
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Fakultät: | Chemie und Pharmazie > Department Chemie |
Themengebiete: | 500 Naturwissenschaften und Mathematik > 540 Chemie |
ISSN: | 1523-7060 |
Sprache: | Englisch |
Dokumenten ID: | 48210 |
Datum der Veröffentlichung auf Open Access LMU: | 27. Apr. 2018, 08:15 |
Letzte Änderungen: | 04. Nov. 2020, 13:25 |