Single-Pot Asymmetric Approach toward Enantioenriched Quaternary Stereocenter-Containing Alkylidenecyclobutanes

Eisold, Michael; Kiefl, Gabriel M. und Didier, Dorian (2016): Single-Pot Asymmetric Approach toward Enantioenriched Quaternary Stereocenter-Containing Alkylidenecyclobutanes. In: Organic Letters, Bd. 18, Nr. 12: S. 3022-3025

Abstract

Enantioenriched alkylidenecyclobutanes possessing a quaternary stereogenic center, usually difficult to access, have been synthesized by combining a double boron-homologation and an allylboration through a highly efficient and diastereoselective one-pot process. Starting from commercially available substrates, this protocol represents a simple way of accessing chiral unsaturated four-membered ring systems with excellent stereoisomeric ratios.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department Chemie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 1523-7060
• Sprache: Englisch