One-Pot Synthesis of Substituted Trifluoromethylated 2,3-Dihydro-1H-imidazoles

Deutsch, Amrei; Jessen, Christoph; Deutsch, Carl; Karaghiosoff, Konstantin and Hoffmann-Röder, Anja (2016): One-Pot Synthesis of Substituted Trifluoromethylated 2,3-Dihydro-1H-imidazoles. In: Organic Letters, Vol. 18, No. 14: pp. 3474-3477

Abstract

An operationally simple one-pot reaction for the preparation of a novel class of racemic trifluoromethylated 2,3dihydro-1H-imidazoles derived from electron-poor N,O-acetals and aryl Grignard reagents is described. In addition, access to highly functionalized 2-trifluoromethyl-2,3-dihydro-1H-imidazoles was accomplished by reaction of N-aryl hemiaminal ethers and N-aryl trifluoroethylamines in the presence of an excess of n-butyllithium.

• Item Type: Journal article
• Faculties: Chemistry and Pharmacy > Department of Chemistry
• Subjects: 500 Science > 540 Chemistry
• ISSN: 1523-7060
• Language: English