Directed Zincation with TMPZnCl-LiCl and Further Functionalization of the Tropolone Scaffold

Haas, Diana; Sustac-Roman, Daniela; Schwarz, Sophia und Knochel, Paul (2016): Directed Zincation with TMPZnCl-LiCl and Further Functionalization of the Tropolone Scaffold. In: Organic Letters, Bd. 18, Nr. 24: S. 6380-6383

Abstract

The directed zincation of tropolone derivatives was achieved using TMPZnCl center dot LiCl. Various functionalizations of the zincated intermediates by halogenation, acylation, allylation, and Negishi cross-coupling were successfully performed. Additionally, 1,8-conjugate addition-elimination reactions with a variety of arylmagnesium and secondary alkylzinc reagents were carried out to further elaborate the tropolone core.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department Chemie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 1523-7060
• Sprache: Englisch