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Haas, Diana; Sustac-Roman, Daniela; Schwarz, Sophia; Knochel, Paul (2016): Directed Zincation with TMPZnCl-LiCl and Further Functionalization of the Tropolone Scaffold. In: Organic Letters, Vol. 18, No. 24: pp. 6380-6383
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The directed zincation of tropolone derivatives was achieved using TMPZnCl center dot LiCl. Various functionalizations of the zincated intermediates by halogenation, acylation, allylation, and Negishi cross-coupling were successfully performed. Additionally, 1,8-conjugate addition-elimination reactions with a variety of arylmagnesium and secondary alkylzinc reagents were carried out to further elaborate the tropolone core.