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Haas, Diana; Sustac-Roman, Daniela; Schwarz, Sophia; Knochel, Paul (2016): Directed Zincation with TMPZnCl-LiCl and Further Functionalization of the Tropolone Scaffold. In: Organic Letters, Vol. 18, Nr. 24: S. 6380-6383
Volltext auf 'Open Access LMU' nicht verfügbar.

Abstract

The directed zincation of tropolone derivatives was achieved using TMPZnCl center dot LiCl. Various functionalizations of the zincated intermediates by halogenation, acylation, allylation, and Negishi cross-coupling were successfully performed. Additionally, 1,8-conjugate addition-elimination reactions with a variety of arylmagnesium and secondary alkylzinc reagents were carried out to further elaborate the tropolone core.