Quantification of the Electrophilicity of Benzyne and Related Intermediates

Nathel, Noah F. Fine; Morrill, Lucas A.; Mayr, Herbert und Garg, Neil K. (2016): Quantification of the Electrophilicity of Benzyne and Related Intermediates. In: Journal of the American Chemical Society, Bd. 138, Nr. 33: S. 10402-10405

Abstract

The determination of reactivity parameters for short-lived intermediates provides an indispensable tool for synthetic design. Despite that electrophilicity parameters have now been established for more than 250 reactive species, the corresponding parameters for benzyne and related intermediates have not been uncovered. We report a study that has allowed for the quantification of benzyne's electrophilicity parameter. Our approach relies on the strategic use of the diffusion -clock method and also provides electrophilicity parameters E for other substituted arynes.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department Chemie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 0002-7863
• Sprache: Englisch