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Vyas, Vijay S.; Vishwakarma, Medhavi; Moudrakovski, Igor; Haase, Frederik; Savasci, Gökcen; Ochsenfeld, Christian; Spatz, Joachim P.; Lotsch, Bettina V. (2016): Exploiting Noncovalent Interactions in an Imine-Based Covalent Organic Framework for Quercetin Delivery. In: Advanced Materials, Vol. 28, No. 39: pp. 8749-8754
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Covalent organic frameworks (COFs) are a new class of nanoporous polymeric vector showing promise as drug-delivery vehicles with high loading capacity and biocompatibility. The interaction between the carrier and the cargo is specifically tailored on a molecular level by H-bonding. Cell-proliferation studies indicate higher efficacy of the drug in cancer cells by nanocarrier delivery mediated by the COF.