Convenient Access to Di- and Trifluoroethylamines for Lead Structure Research

Deutsch, Amrei; Wagner, Christian; Deutsch, Carl and Hoffmann-Röder, Anja (2016): Convenient Access to Di- and Trifluoroethylamines for Lead Structure Research. In: European Journal of Organic Chemistry, No. 5: pp. 930-945

Abstract

Much research effort has been devoted to the synthesis of fluorinated organic compounds in medicinal chemistry programs. For instance, incorporation of fluorine substituents and trifluoromethyl groups has become a widespread lead optimization strategy owing to the often favorable influence of such moieties on affinity and physicochemical properties. However, introduction of fluoroalkyl groups into dedicated positions of pharmacophores is synthetically challenging. In particular, efficient syntheses of di- and trifluoroethylamines are needed as they are an interesting, yet underrepresented, class of carboxamide mimics. Thus, a practical and reliable protocol for their preparation is described by using functionalized di- and trifluoromethylated N-aryl-substituted N,O-acetals as synthetic aldimine equivalents. Moreover, previously unknown -trifluoroethylamine analogs of 1,2-dihydroquinazolin-4(1H)-thione and the androgen receptor antagonist DIMN are prepared to demonstrate the method's applicability.

• Item Type: Journal article
• Faculties: Chemistry and Pharmacy > Department of Chemistry
• Subjects: 500 Science > 540 Chemistry
• ISSN: 1434-193X
• Language: English