Gold(I)-Catalyzed Enyne Cyclizations: Studies Toward the Total Synthesis of (+)-Aureol

Wildermuth, Raphael; Speck, Klaus and Magauer, Thomas (2016): Gold(I)-Catalyzed Enyne Cyclizations: Studies Toward the Total Synthesis of (+)-Aureol. In: Synthesis-Stuttgart, Vol. 48, No. 12: pp. 1814-1824

Abstract

We report a modular synthetic approach toward the total synthesis of (+)-aureol based on a bioinspired gold(I)-catalyzed enyne cascade cyclization reaction. First, we investigated an array of catalysts to promote a 6-endo-dig cyclization of a highly advanced enediyne precursor. Since these studies result exclusively in the formation of the 5-exo-dig product, we synthesized and investigated a dienyne cyclization precursor in order to form the benzo[d]xanthene skeleton in a stepwise fashion.

• Item Type: Journal article
• Faculties: Chemistry and Pharmacy > Department of Chemistry
• Subjects: 500 Science > 540 Chemistry
• ISSN: 0039-7881
• Language: English