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Quinio, Pauline; Kohout, Laura; Sustac Roman, Daniela; Gaar, Jakob; Karaghiosoff, Konstantin; Knochel, Paul (2016): Sc(OTf)₃-Catalyzed Addition of Bromomagnesium 2-Vinyloxy Ethoxide to Various Aldehydes Leading to Protected Aldol Products. In: Synlett, Vol. 27, No. 11: pp. 1715-1719
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The addition of bromomagnesium 2-vinyloxy ethoxide to various aldehydes in the presence of 10 mol% Sc(OTf)(3) provides a broad range of functionalized protected aldol compounds. The enantioselective preparation of these aldols can be achieved via a Swern oxidation-CBS reduction sequence. Use of the dioxolane derived from 2-bromocyclohexanone provides the expected aldol product as the anti diastereoisomer (dr >99:1).