Mild Cobalt-Catalyzed Negishi Cross-Couplings of (Hetero)arylzinc Reagents with (Hetero)aryl Halides

Haas, Diana; Hammann, Jeffrey M.; Lutter, Ferdinand H. and Knochel, Paul (2016): Mild Cobalt-Catalyzed Negishi Cross-Couplings of (Hetero)arylzinc Reagents with (Hetero)aryl Halides. In: Angewandte Chemie-international Edition, Vol. 55, No. 11: pp. 3809-3812

Abstract

A catalytic system consisting of CoCl(2)2LiCl (5mol%) and HCO2Na (50mol%) enables the cross-coupling of various N-heterocyclic chlorides and bromides as well as aromatic halogenated ketones with various electron-rich and -poor arylzinc reagents. The reactions reached full conversion within a few hours at 25 degrees C.

• Item Type: Journal article
• Faculties: Chemistry and Pharmacy > Department of Chemistry
• Subjects: 500 Science > 540 Chemistry
• ISSN: 1433-7851
• Language: English