Highly diastereoselective approach to methylenecyclopropanes via boron-homologation/allylboration sequences

Baumann, Andreas N.; Music, Arif; Karaghiosoff, Konstantin und Didier, Dorian (2016): Highly diastereoselective approach to methylenecyclopropanes via boron-homologation/allylboration sequences. In: Chemical Communications, Bd. 52, Nr. 12: S. 2529-2532

Abstract

A simple and efficient diastereoselective synthesis of methylenecyclopropanes is described, in which boron-homologation and allylboration are merged into a one-pot process, starting from in situ generated cyclopropenyllithium species. This unprecedented methodology opens a new route to strained alkylidenecycloalkanes containing a quaternary stereocenter, in high yields and excellent diastereomeric ratios.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department Chemie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 1359-7345
• Sprache: Englisch