Abstract
N-Acylhomoserine lactones are autoinducers of quorum sensing (QS) in Gram-negative bacteria. We exploit here the role of structurally related beta-lactones in the inhibition of Vibrio harveyi bioluminescence and identify a derivative with nanomolar potency. Surprisingly, QS was not affected and combined proteomic/biochemical studies revealed insights into the cellular mode of action.
Item Type: | Journal article |
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Faculties: | Biology > Department Biology I |
Research Centers: | Center for Integrated Protein Science Munich (CIPSM) |
Subjects: | 500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry |
ISSN: | 1359-7345 |
Language: | English |
Item ID: | 48836 |
Date Deposited: | 27. Apr 2018, 08:16 |
Last Modified: | 04. Nov 2020, 13:26 |