Mechanistic analysis of aliphatic β-lactones in Vibrio harveyi reveals a quorum sensing independent mode of action

Zhao, Weining; Lorenz, Nicola; Jung, Kirsten; Sieber, Stephan A. (2016): Mechanistic analysis of aliphatic β-lactones in Vibrio harveyi reveals a quorum sensing independent mode of action. In: Chemical Communications, Vol. 52, No. 80: pp. 11971-11974

Abstract

N-Acylhomoserine lactones are autoinducers of quorum sensing (QS) in Gram-negative bacteria. We exploit here the role of structurally related beta-lactones in the inhibition of Vibrio harveyi bioluminescence and identify a derivative with nanomolar potency. Surprisingly, QS was not affected and combined proteomic/biochemical studies revealed insights into the cellular mode of action.

• Item Type: Journal article
• Faculties: Biology > Department Biology I
• Research Centers: Center for Integrated Protein Science Munich (CIPSM)
• Subjects: 500 Science > 570 Life sciences; biology; 500 Science > 540 Chemistry
• ISSN: 1359-7345
• Language: English