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Zhao, Weining; Lorenz, Nicola; Jung, Kirsten and Sieber, Stephan A. (2016): Mechanistic analysis of aliphatic β-lactones in Vibrio harveyi reveals a quorum sensing independent mode of action. In: Chemical Communications, Vol. 52, No. 80: pp. 11971-11974

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N-Acylhomoserine lactones are autoinducers of quorum sensing (QS) in Gram-negative bacteria. We exploit here the role of structurally related beta-lactones in the inhibition of Vibrio harveyi bioluminescence and identify a derivative with nanomolar potency. Surprisingly, QS was not affected and combined proteomic/biochemical studies revealed insights into the cellular mode of action.

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