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Goebbels, Sandra; Wieser, Georg L.; Pieper, Alexander; Spitzer, Sonia; Weege, Bettina; Yan, Kuo; Edgar, Julia M.; Yagensky, Oleksandr; Wichert, Sven P.; Agarwal, Amit; Karram, Khalad; Renier, Nicolas; Tessier-Lavigne, Marc; Rossner, Moritz J.; Karadottir, Ragnhildur Thora; Nave, Klaus-Armin (2017): A neuronal PI(3,4,5)P-3-dependent program of oligodendrocyte precursor recruitment and myelination. In: Nature Neuroscience, Vol. 20, No. 1: pp. 10-15
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The molecular trigger of CNS myelination is unknown. By targeting Pten in cerebellar granule cells and activating the AKT1-mTOR pathway, we increased the caliber of normally unmyelinated axons and the expression of numerous genes encoding regulatory proteins. This led to the expansion of genetically wild-type oligodendrocyte progenitor cells, oligodendrocyte differentiation and de novo myelination of parallel fibers. Thus, a neuronal program dependent on the phosphoinositide P1(3,4,5)P-3 is sufficient to trigger all steps of myelination.