Whom to Treat Postdiagnostic Risk Assessment with Gleason Score, Risk Models, and Genomic Classifier

Herlemann, Annika; Washington, Samuel L.; Eapen, Renu S. und Cooperberg, Matthew R. (2017): Whom to Treat Postdiagnostic Risk Assessment with Gleason Score, Risk Models, and Genomic Classifier. In: Urologic Clinics of North America, Bd. 44, Nr. 4: S. 547-555

Abstract

Management of prostate cancer presents unique challenges because of the disease's variable natural history. Accurate risk stratification at the time of diagnosis in clinically localized disease is crucial in providing optimal counseling about management options. To accurately distinguish pathologically indolent tumors from aggressive disease, risk groups are no longer sufficient. Rather, multivariable prognostic models reflecting the complete information known at the time of diagnosis offer improved accuracy and interpretability. After diagnosis, further testing with genomic assays or other biomarkers improves risk classification. These postdiagnostic risk assessment tools should not supplant shared decision making but rather facilitate risk classification and enable more individualized care.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0094-0143
• Sprache: Englisch