Abstract
Objective: To investigate the occurrence of ictal and postictal aphasia in different focal epilepsy syndromes. Methods: Weretrospectively analyzed the video-electroencephalographic monitoring data of 1,118 patients with focal epilepsy for seizure-associated aphasia (SAA). Statistical analysis included chi-square analysis and Fisher's exact test. Results: We identified 102 of 1,118 patients (9.1%) in whom ictal or postictal aphasia (SAA) was part of their recorded seizures (n = 59 of 102;57.8%) or who reported aphasia by history (n = 43;42.2% only reported aphasia by history). Postictal aphasia was present in 18 patients (30.5%). Six of the 59 patients had both ictal and postictal aphasia (10.2%). SAA occurred either with left hemisphere seizure onset or with seizures spreading from the right to the left hemisphere. SAA was most common in patients with parieto-occipital epilepsy (10.9%;five of 46 patients), followed by patients with temporal (6.7%;28 of 420 patients), focal (not further localized;4.8%;22 of 462 patients), and frontal epilepsy (2.1%;four of 190 patients;p = 0.04). SAA was more common in parieto-occipital epilepsy than in frontal epilepsy (p = 0.02). In contrast, there was no significant difference in SAA between temporal and parieto-occipital epilepsy (p = 0.36). Significance: SAA has a high lateralizing but limited localizing value, as it often reflects spread of epileptic activity into speech-harboring brain regions.
Item Type: | Journal article |
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Faculties: | Medicine |
Subjects: | 600 Technology > 610 Medicine and health |
ISSN: | 0013-9580 |
Language: | English |
Item ID: | 50298 |
Date Deposited: | 14. Jun 2018, 09:43 |
Last Modified: | 04. Nov 2020, 13:27 |