Seizure-associated aphasia has good lateralizing but poor localizing significance

Loesch, Anna Mira; Steger, Hannah; Losher, Claudia; Hartl, Elisabeth; Remi, Jan; Vollmar, Christian und Noachtar, Soheyl (2017): Seizure-associated aphasia has good lateralizing but poor localizing significance. In: Epilepsia, Bd. 58, Nr. 9: S. 1551-1555

Abstract

Objective: To investigate the occurrence of ictal and postictal aphasia in different focal epilepsy syndromes. Methods: Weretrospectively analyzed the video-electroencephalographic monitoring data of 1,118 patients with focal epilepsy for seizure-associated aphasia (SAA). Statistical analysis included chi-square analysis and Fisher's exact test. Results: We identified 102 of 1,118 patients (9.1%) in whom ictal or postictal aphasia (SAA) was part of their recorded seizures (n = 59 of 102;57.8%) or who reported aphasia by history (n = 43;42.2% only reported aphasia by history). Postictal aphasia was present in 18 patients (30.5%). Six of the 59 patients had both ictal and postictal aphasia (10.2%). SAA occurred either with left hemisphere seizure onset or with seizures spreading from the right to the left hemisphere. SAA was most common in patients with parieto-occipital epilepsy (10.9%;five of 46 patients), followed by patients with temporal (6.7%;28 of 420 patients), focal (not further localized;4.8%;22 of 462 patients), and frontal epilepsy (2.1%;four of 190 patients;p = 0.04). SAA was more common in parieto-occipital epilepsy than in frontal epilepsy (p = 0.02). In contrast, there was no significant difference in SAA between temporal and parieto-occipital epilepsy (p = 0.36). Significance: SAA has a high lateralizing but limited localizing value, as it often reflects spread of epileptic activity into speech-harboring brain regions.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0013-9580
• Sprache: Englisch