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Simon, Thorsten; Hero, Barbara; Schulte, Johannes H.; Deubzer, Hedwig; Hundsdoerfer, Patrick; Schweinitz, Dietrich von; Fuchs, Jörg; Schmidt, Matthias; Prasad, Vikas; Krug, Barbara; Timmermann, Beate; Leuschner, Ivo; Fischer, Matthias; Langer, Thorsten; Astrahantseff, Kathy; Berthold, Frank; Lode, Holger and Eggert, Angelika (2017): 2017 GPOH Guidelines for Diagnosis and Treatment of Patients with Neuroblastic Tumors. In: Klinische Pädiatrie, Vol. 229, No. 3: pp. 147-167

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Abstract

The clinical course of neuroblastoma is more heterogeneous than any other malignant disease. Most low-risk patients experience regression after limited or even no chemotherapy. However, more than half of high-risk patients die from disease despite intensive multimodal treatment. Precise patient characterization at diagnosis is key for risk-adapted treatment. The guidelines presented here incorporate results from national and international clinical trials to produce recommendations for diagnosing and treating neuroblastoma patients in German hospitals outside of clinical trials.

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