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Stentzel, Sebastian; Hagl, Beate; Abel, Felicitas; Kahl, Barbara C.; Rack-Hoch, Anita; Bröker, Barbara M.; Renner, Ellen D. (2017): Reduced Immunoglobulin (Ig) G Response to Staphylococcus aureus in STAT3 Hyper-IgE Syndrome. In: Clinical infectious Diseases, Vol. 64, Nr. 9: S. 1279-1282
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Abstract

STAT3 hyper-IgE syndrome (STAT3-HIES) patients presented with significantly lower Staphylococcus aureus-specific serum IgG compared to cystic fibrosis patients despite recurrent S. aureus infections. Immunoglobulin replacement therapy increased S. aureus-specific IgG in STAT3-HIES patients and attenuated the clinical course of disease suggesting a role of humoral immunity in S. aureus clearance.