Small but mighty: Platelets as central effectors of host defense

Stocker, Thomas J.; Ishikawa-Ankerhold, Hellen; Massberg, Steffen und Schulz, Christian (2017): Small but mighty: Platelets as central effectors of host defense. In: Thrombosis and Haemostasis, Bd. 117, Nr. 4: S. 651-661

Abstract

Platelets actively participate in inflammatory processes and drive diseases such as atherosclerosis, rheumatoid arthritis and cancer metastasis. However, platelets also have anti-inflammatory and anti-infective properties, which have received less consideration in the past. In this review, we highlight recent findings on the role of platelets in host defense and describe regulatory pathways modulating immune responses. Furthermore, we discuss the role of platelets for the resolution of inflammation and tissue repair. These conceptual changes contribute to our understanding of platelet biology in disease.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0340-6245
• Sprache: Englisch