Pathologie und Pathogenese der progredienten Multiplen Sklerose: Konzepte und Kontroversen

Schumacher, Adrian-Minh; Mahler, Christoph und Kerschensteiner, Martin (2017): Pathologie und Pathogenese der progredienten Multiplen Sklerose: Konzepte und Kontroversen. In: Aktuelle Neurologie, Bd. 44, Nr. 7: S. 476-488

Abstract

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system that initially is often dominated by relapsing-remitting neurological symptoms. With increasing disease duration, these relapses are more and more superimposed by a progressive disease process that leads to irreversible accumulation of motor, sensory and cognitive deficits. This progressive phase of MS is still only incompletely understood and by and large refractory to therapy. Here we aim to use recent pathological and pathomechanistic insights to outline a unifying pathomechanistic concept of progressive MS. Based on this view of the disease, we examine current controversies surrounding progressive MS. We discuss whether neurodegenerative or inflammatory processes drive progression, and whether the classification of primary and secondary progressive MS is all that useful;we also consider which therapeutic strategies are best suited to limit the insidious decline of progressive MS-patients.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0302-4350
• Sprache: Deutsch