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Knabl, Julia; Vattai, Aurelia; Ye, Yao; Jückstock, Julia; Hutter, Stefan; Kainer, Franz; Mahner, Sven; Jeschke, Udo (2017): Role of Placental VDR Expression and Function in Common Late Pregnancy Disorders. In: International Journal of Molecular Sciences, Vol. 18, No. 11, 2340


Vitamin D, besides its classical role in bone metabolism, plays a distinct role in multiple pathways of the feto-maternal unit. Calcitriol is the major active ligand of the nuclear vitamin D receptor (VDR). The vitamin D receptor (VDR) is expressed in different uteroplacental parts and exerts a variety of functions in physiologic pregnancy. It regulates decidualisation and implantation, influences hormone secretion and placental immune modulations. This review highlights the role of the vitamin D receptor in physiologic and disturbed pregnancy, as preeclampsia, fetal growth restriction, gestational diabetes and preterm birth. We discuss the existing literature regarding common VDR polymorphisms in these pregnancy disorders.