Role of Placental VDR Expression and Function in Common Late Pregnancy Disorders

Knabl, Julia; Vattai, Aurelia; Ye, Yao; Jückstock, Julia; Hutter, Stefan; Kainer, Franz; Mahner, Sven und Jeschke, Udo (2017): Role of Placental VDR Expression and Function in Common Late Pregnancy Disorders. In: International Journal of Molecular Sciences, Bd. 18, Nr. 11, 2340

Abstract

Vitamin D, besides its classical role in bone metabolism, plays a distinct role in multiple pathways of the feto-maternal unit. Calcitriol is the major active ligand of the nuclear vitamin D receptor (VDR). The vitamin D receptor (VDR) is expressed in different uteroplacental parts and exerts a variety of functions in physiologic pregnancy. It regulates decidualisation and implantation, influences hormone secretion and placental immune modulations. This review highlights the role of the vitamin D receptor in physiologic and disturbed pregnancy, as preeclampsia, fetal growth restriction, gestational diabetes and preterm birth. We discuss the existing literature regarding common VDR polymorphisms in these pregnancy disorders.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1422-0067
• Sprache: Englisch