Soluble intercellular adhesion molecule-1: a potential biomarker for pain intensity in chronic pain patients

Luchting, Benjamin; Hinske, Ludwig Christian Giuseppe; Rachinger-Adam, Banafscheh; Celi, Leo Anthony; Kreth, Simone und Azad, Shahnaz Christina (2017): Soluble intercellular adhesion molecule-1: a potential biomarker for pain intensity in chronic pain patients. In: Biomarkers in Medicine, Bd. 11, Nr. 3: S. 265-276

Abstract

Aim: Pain therapy is strongly guided by patients' self-reporting. However, when self-reporting is not an option, pain assessment becomes a challenge and may lead to undertreatment of painful conditions. Pain is a complex and multifactorial phenomenon. Recent work has connected pain pathophysiology also with the inflammatory system. We therefore hypothesized that pain intensity could be predicted by cytokine-levels. Patients & methods: In this observational, single-center study, we investigated 30 serum cytokines to predict pain intensity in a screening/follow-up set of 95 chronic pain patients and controls. We then prospectively validated soluble intercellular adhesion molecule-1 (sICAM-1)'s discriminatory capability (n = 21). Results & conclusion: sICAM-1 was significantly associated with patient-reported pain intensity and yielded differential serum levels in patients of varying degrees of pain intensity. Changes in pain ratings over time correlated with changes in sICAM-1 levels. Our findings suggest the possibility of a clinical use of sICAM-1 as a potential biomarker for pain intensity.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1752-0363
• Sprache: Englisch