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Käsmacher, Johannes; Huber, Thomas; Lehm, Manuel; Zimmer, Claus; Bernkopf, Kathleen; Wunderlich, Silke; Böckh-Behrens, Tobias; Manning, Nathan W.; Kleine, Justus F. (2017): Isolated Striatocapsular Infarcts after Endovascular Treatment of Acute Proximal middle Cerebral Artery Occulusion: Prevalence, Enabling Factors, and Clinical Outcomes. In: Frontiers in Neurology, Vol. 8, 272
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Background: Striatocapsular infarcts (SCIs) are defined as large subcortical infarcts involving the territory of more than one lenticulostriate artery. SCI without concomitant ischemia in the more distal middle cerebral artery (MCA) territory [isolated SCI (iSCI)] has been described as a rare infarct pattern. The purpose of this study was to assess the prevalence of iSCI in patients treated with endovascular thrombectomy (ET), to evaluate baseline and procedural parameters associated with this condition, and to describe the clinical course of iSCI patients. Methods: A retrospective analysis of 206 consecutive patients with an isolated MCA occlusion involving the lenticulostriate arteries and treated with ET was performed. Baseline patient and procedural characteristics and ischemic involvement of the striatocapsular and distal MCA territory [iSCI, as opposed to non-isolated SCI (niSCI)] were analyzed using multivariate logistic regression models. Prevalence of iSCI was assessed, and clinical course was determined with the rates of substantial neurological improvement and good functional short-and mid-term outcome (discharge/day 90 Modified Rankin Scale <= 2). Results: iSCI was detected in 53 patients (25.7%), and niSCI was detected in 153 patients (74.3%). Successful reperfusion [thrombolysis in cerebral infarction (TICI) 2b/3] [adjusted odds ration (aOR) 8.730, 95% confidence interval (95% CI) 1.069-71.308] and good collaterals (aOR 2.100, 95% CI 1.119-3.944) were associated with iSCI. In successfully reperfused patients, TICI 3 was found to be an additional factor associated with iSCI (aOR 5.282, 1.759-15.859). Patients with iSCI had higher rates of substantial neurological improvement (71.7 vs. 37.9%, p < 0.001) and higher rates of good functional short-and mid-term outcome (58.3 vs. 23.7%, p < 0.001 and 71.4 vs. 41.7%, p < 0.001). However, while iSCI patients, in general, had a more favorable outcome, considerable heterogeneity in outcome was observed. Conclusion: High rates of successful reperfusion (TICl 2b/3) and in particular, complete reperfusion (TICl 3) are associated with iSCls. The high prevalence iSCl in successfully reperfused patients with good collaterals corroborates previous concepts of iSCl partho-genesis. iSCl, once considered a rare pattern of cerebral ischemia, is likely to become more prevalent with increase in endovascular stroke therapy. This may have implications for patient rehabilitation and pathophysiological analysis of ischemic damage confind to subcortical regions of the MCA territory.