Higher serum 25(OH)D concentrations are associated with improved FEV1 and FVC in adolescence

Flexeder, Claudia; Thiering, Elisabeth; Koletzko, Sibylle; Berdel, Dietrich; Lehmann, Irina; Berg, Andrea von; Hoffmann, Barbara; Bauer, Carl-Peter; Heinrich, Joachim und Schulz, Holger (2017): Higher serum 25(OH)D concentrations are associated with improved FEV1 and FVC in adolescence. In: European Respiratory Journal, Bd. 49, Nr. 4, 1601804

Abstract

Vitamin D plays a role in the development of the immune system and the lung, as well as in airway remodelling. Therefore, this study investigated the association between serum 25-hydroxyvitamin D (25(OH) D) concentrations and spirometric lung function parameters at age 15 years. In the German birth cohorts GINIplus and LISAplus, lung function testing by spirometry and 25(OH) D measurements were performed during the 15-year follow-up examinations. Valid lung function measurements pre-and/or post-bronchodilation and serum 25(OH) D concentrations, which were adjusted for the date of blood sampling to account for seasonal variability, were available for 2607 adolescents. Associations between 25(OH) D concentrations and spirometric parameters were analysed using generalised additive models adjusted for confounding factors. Serum 25(OH) D concentrations were significantly associated with forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1) and FEV1/FVC measured before bronchodilation after adjustment for potential confounders: FEV1 increased by 10 mL (95% CI 2-17), FVC by 20 mL (95% CI 12-28) and FEV1/FVC decreased by 0.177% (95% CI -0.286 to -0.067) per 10 nmol.L-1 increase in 25(OH) D concentrations. Flow rates (forced expiratory flow rates at 25, 50 and 75% of exhaled FVC (FEF25, FEF50, FEF75) and mean flow rate between 25 and 75% of FVC (FEF25-75)) were not associated with vitamin D. Similar associations were observed for lung function parameters measured after bronchodilation. Vitamin D concentrations are positively associated with volume-related lung function parameters preand post-bronchodilation, suggesting structural changes in peripheral airways.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0903-1936
• Sprache: Englisch