Neutrophils as protagonists and targets in chronic inflammation

Söhnlein, Oliver; Steffens, Sabine; Hidalgo, Andres and Weber, Christian (2017): Neutrophils as protagonists and targets in chronic inflammation. In: Nature Reviews Immunology, Vol. 17, No. 4: pp. 248-261

Abstract

Traditionally, neutrophils have been acknowledged to be the first immune cells that are recruited to an inflamed tissue and have mainly been considered in the context of acute inflammation. By contrast, their importance during chronic inflammation has been studied in less depth. This Review aims to summarize our current understanding of the roles of neutrophils in chronic inflammation, with a focus on how they communicate with other immune and non-immune cells within tissues. We also scrutinize the roles of neutrophils in wound healing and the resolution of inflammation, and finally, we outline emerging therapeutic strategies that target neutrophils.

• Item Type: Journal article
• Faculties: Medicine
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 1474-1733
• Language: English