Chronische cholestatische Leberkrankheiten. Differenzialdiagnose, Pathogenese und aktuelle Therapie beim Erwachsenen

Hohenester, S. und Beuers, U. (2017): Chronische cholestatische Leberkrankheiten. Differenzialdiagnose, Pathogenese und aktuelle Therapie beim Erwachsenen. In: Internist, Bd. 58, Nr. 8: S. 805-825

Abstract

In the long-term course chronic cholestasis regularly leads to fibrotic restructuring and ultimately to functional failure of the liver, independent of the cause. Cholestatic diseases are often clinically asymptomatic. In order to avoid progression, early diagnosis of the underlying disease and a targeted therapy are therefore decisive. The differential diagnoses of chronic cholestasis are broad;therefore, algorithms are of assistance in the diagnostic work-up. A better understanding of the pathogenesis is now leading to the development of new therapeutic agents in addition to ursodeoxycholic acid, which has long been known for its anticholestatic effects. Obeticholic acid and, in the near future, bezafibrate are therapeutic options. The possibilities for genetic diagnostics of unclear cholestasis syndromes improve the understanding of the pathogenesis of many diseases and are being introduced increasingly earlier into the clinical routine.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0020-9554
• Sprache: Deutsch