Abstract
Background Left ventricular (LV) volumetric and functional parameters measured with cardiac computed tomography (cardiac CT) augment risk prediction and discrimination for future mortality. Gender-and age-specific standard values for LV dimensions and systolic function obtained by 64-slice cardiac CT are lacking. Methods and results 1155 patients from the Coronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter registry (54.5% males, mean age 53.1 +/- 12.4 years, range: 18-92 years) without known coronary artery disease (CAD), structural heart disease, diabetes, or hypertension who underwent cardiac CT for various indications were categorized according to age and sex. A cardiac CT data acquisition protocol was used that allowed volumetric measuring of LV function. Image interpretation was performed at each site. Patients with significant CAD(. 50% stenosis) on cardiac CT were excluded from the analysis. Overall, mean left ventricular ejection fraction (LVEF) was higher in women when compared with men (66.6 +/- 7.7% vs. 64.6 +/- 8.1%, P < 0.001). This gender-difference in overall LVEF was caused by a significantly higher LVEF in women >= 70 years when compared with men >= 70 years (69.95 +/- 8.89% vs. 65.50 +/- 9.42%, P = 0.004). Accordingly, a significant increase in LVEF was observed with age (P = 0.005 for males and P, 0.001 for females), which was more pronounced in females (5.21%) than in males 2.6%). LV end-diastolic volume decreased in females from 122.48 +/- 27.87 (< 40 years) to 95.56 +/- 23.17 (>= 70 years;P < 0.001) and in males from 155.22 +/- 35.07 (< 40 years) to 130.26 +/- 27.18 (>70 years;P < 0.001). Conclusion Our findings indicate that the LV undergoes a lifelong remodelling and highlight the need for age and gender adjusted reference values.
Item Type: | Journal article |
---|---|
Faculties: | Medicine |
Subjects: | 600 Technology > 610 Medicine and health |
ISSN: | 2047-2404 |
Language: | English |
Item ID: | 52054 |
Date Deposited: | 14. Jun 2018, 09:48 |
Last Modified: | 04. Nov 2020, 13:30 |