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Orban, Mathias; Orban, Martin; Lesevic, Hasema; Braun, Daniel; Deseive, Simon; Sonne, Carolin; Hutterer, Lisa; Grebmer, Christian; Khandoga, Alexander; Pache, Jürgen; Mehilli, Julinda; Schunkert, Heribert; Kastrati, Adnan; Hagl, Christian; Bauer, Axel; Massberg, Steffen; Bökstegers, Peter; Näbauer, Michael; Ott, Ilka; Hausleiter, Jörg (2017): Predictors for long-term survival after transcatheter edge-to-edge mitral valve repair. In: Journal of interventional Cardiology, Vol. 30, No. 3: pp. 226-233
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Abstract

Objectives: To determine predictors for long-term outcome in high-risk patients undergoing transcatheter edge-to-edge mitral valve repair (TMVR) for severe mitral regurgitation (MR). Background: There is no data on predictors of long-term outcome in high-risk real-world patients. Methods: From August 2009 to April 2011, 126 high-risk patients deemed inoperable were treated with TMVR in two high-volume university centers. Results: MR could be successfully reduced to grade <= 2 in 92.1% of patients (116/126 patients). Longterm clinical follow-up up to 5 years (95.2% follow-up rate) revealed a mortality rate of 35.7% (45/126 patients). Repeat mitral valve treatment (surgery or intervention) was needed in 19 patients (15.1%). Long-term clinical improvement was demonstrated with 69% of patients being in NYHA class <= II. In a multivariable Cox regression analysis, the post-procedural grade of MR (hazard ratio [HR] 1.55 per grade, P = 0.035), the left ventricular ejection fraction (HR 0.58 for difference between 75th and 25th percentile, P = 0.031) and the glomerular filtration rate (HR0.33 for 75th vs 25th percentile, P < 0.001) were independent predictors for long-term mortality. Patients with primary MR and a post-procedural MR grade = 1 had the most favorable long-term outcome. Conclusions: This study determines predictors of long-term clinical outcome after TMVR and demonstrates that the grade of residual MR determines long-term survival. Our data suggest that it might be of benefit reducing residual MR to the lowest possible MR grade using TMVR-especially in selected high-risk patients with primary MR who are not considered as candidates for surgical MVR.