Influence of vitamin D signaling on hormone receptor status and HER2 expression in breast cancer

Zhang, Xi; Harbeck, Nadia; Jeschke, Udo und Doisneau-Sixou, Sophie (2017): Influence of vitamin D signaling on hormone receptor status and HER2 expression in breast cancer. In: Journal of Cancer Research and Clinical Oncology, Bd. 143, Nr. 7: S. 1107-1122

Abstract

Breast cancer is a significant global public health issue. It is the leading cause of death among women around the world, with an incidence increasing annually. In recent years, there has been more and more information in the literature regarding a protective role of vitamin D in cancer. Increasingly preclinical and clinical studies suggest that vitamin D optimal levels can reduce the risk of breast cancer development and regulate cancer-related pathways. In this review, we focus on the importance of vitamin D in breast cancers, discussing especially the influence of vitamin D signaling on estrogen receptor and human epidermal growth factor receptor 2 (HER2), two major biomarkers of breast cancer today. We discuss the possibility of actual and future targeted therapeutic approaches for vitamin D signaling in breast cancer.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0171-5216
• Sprache: Englisch