Abstract
Background-To assess the vessel-healing pattern of Ultimaster drug-eluting stent using optical frequency domain imaging. Our hypothesis is that biodegradable polymer-based drug-eluting technology allows complete very early strut coverage. Methods and Results-The DISCOVERY 1TO3 study (Evaluation With OFDI of Strut Coverage of Terumo New Drug Eluting Stent With Biodegradable Polymer at 1, 2, and 3 Months) is a prospective, single-arm, multicenter study. A total of 60 patients with multivessel disease requiring staged procedure at 1 month were treated with Ultimaster. Optical frequency domain imaging was acquired at baseline, 1, 2, and 3 months. The primary end point is optical frequency domain imaging-assessed strut coverage at 3 months. Mean age of patients was 67.2 +/- 9.9 years, and 73.3% were male, and 36.7% presented with acute coronary syndrome. A total of 132 lesions were treated, with average 1.4 lesions per patient treated at baseline and 1.1 lesions treated at 1 month. Strut coverage at 3 months of single implanted stents (n=71, primary end point) was 95.2 +/- 5.2% and of combined single and overlapped stents was 95.4 +/- 4.9%. Strut coverage of combined single and overlapped stents at 1 (n=49) and 2 months (n=38) was 85.1 +/- 12.7% and 87.9 +/- 10.8%, respectively. The median neointimal hyperplasia thickness was 0.04, 0.05, and 0.06 mm, whereas mean neointimal hyperplasia obstruction was 4.5 +/- 2.4%, 5.2 +/- 3.4%, and 6.6 +/- 3.3% at 1, 2, and 3 months, respectively. Conclusions-Nearly complete strut coverage was observed in this complex population very early after implantation of Ultimaster drug-eluting stent.
Dokumententyp: | Zeitschriftenartikel |
---|---|
Fakultät: | Medizin |
Themengebiete: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit |
ISSN: | 1941-7640 |
Sprache: | Englisch |
Dokumenten ID: | 52230 |
Datum der Veröffentlichung auf Open Access LMU: | 14. Jun. 2018, 09:49 |
Letzte Änderungen: | 04. Nov. 2020, 13:30 |